AAV Viruses

Premade AAV Viruses

AAV Viruses

Premade AAV viruses or AAV vectors offer a convenient solution for researchers conducting gene delivery experiments, including gene therapy, gene editing, and gene regulation. AAVnerGene provides a diverse selection of premade AAV viruses in various serotypes, promoters, and reporters/transgenes, enabling researchers to select the most suitable AAVs for their specific applications. With over 1000 known AAV serotypes, customers can quickly determine the AAV specificity for different cell types. Additionally, multiple promoters paired with reporter genes facilitate the assessment and tracking of specific gene expression levels and timing.
Most of the premade AAV viruses are produced using our innovative  AAVdual® systems, and corresponding pAAVdual plasmids are also available for purchase. This comprehensive offering streamlines the research process and enhances the potential for successful gene delivery outcomes.

 

AAV SerotypesAAV1, AAV2, AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh.10,AAV11, AAV12, AAV13, AAV-DJ, AAVrh.74, AAV2-retro and more than 1000 AAV capsids in house. 
PromotersEF1a, hSyn, GFAP, CAG, GfaABC1D, CaMKIIα, CaMKIIα(0.36), mTyr, TBG, SP-B, MHCK7, rNSE, hRHO, ApoE/hAAT, ACTA1, CD144, CK8e, TERT, EnSM22a, CD68, MIR218, Col2a1, TUBA1A, MMTV, cTnT, K14, Grm6, Tie1, hBEST1, Nanog, Myog, Iba1, 4XGRM6, Ins2, and  more. 
TransgenesReporter genes (such as EGFP, mCherry, TdTomato, Cre, iCre, Gluc, Cluc, Fluc, Rluc), DIO systems, shRNAs, sgRNAs for different gene editing systems, and ORFs from ORFeome collections.
 scAAV Self-complementary AAV (scAAV) is a powerful tool for researchers requiring rapid, efficient, and stable transgene expression.

To ensure the highest quality and purity of its premade AAV viruses, AAVnerGene employs a range of rigorous assays to characterize AAV vectors:

  • Gene specific qPCR Titer: Target the specific transgenes or common used elements, such as WPRE, CMV, PolyA, but not ITR.
  • Full/Empty Particle Ratio: Ensure all the premade AAVs has >80% full particles by Mass Photometry.
  • Endotoxin Testing: Ensure safety with endotoxin level <1U/1e13VG. 
  • SDS-PAGE Gel: Assess the purity of the AAV viruses is great than 95%.
  • Infectivity Assay: Evaluate the efficiency of AAV viruses in transducing target cells if they have reporters.

The high purity and quality of AAVnerGene’s premade AAV viruses offer significant advantages to customers, including reduced optimization efforts, lower labor requirements, and minimal expertise needed. This ensures reliable and consistent results for both in vitro and in vivo applications.

AAV Viruses with Different Promoters and Reporters

Common AAV serotypes are available  (AAV1, AAV2, AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh.10,AAV11, AAV12, AAV13, AAV-DJ, AAVrh.74, AAV2-retro)  and more than 1000 AAV capsids in house . 

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