Revolutionize Gene Therapy by Advancing AAV Technology for Safe, Effective, and Affordable Therapies

Our AAV Technologies and Solutions

AAV Products

At AAVnerGene, we specialize in advancing the frontiers of gene therapy through cutting-edge AAV technologies, services and products. Our comprehensive AAV products are tailored to meet the diverse needs of researchers, clinicians, and biotechnology companies.

AAV Plasmids
AAV plasmids for different production systems (AAVone, AAVdual, and AAVtri) and AAV barcode plasmids for capsid evaluation
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AAV Viruses
High-quality premade AAV vectors, tools, biosensors (serotypes, promoters, and transgenes) for gene delivery and gene therapy
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AAV Biosensors
Constitutive, Cre-dependent or Flp-dependent; Sensitive, cell-type–specific, and longitudinal tracking of biological processes
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AAV References
Three well-characterized AAV reference materials (full AAV particles, truly-empty AAV particles and byproduct empty AAV particles) for your needs
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AAV Capsid Kits
AAV capsid barcode kits and AAV serotype testing kits to evaluate & select the best AAV serotypes and AAV variants for specific applications
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AAV Capsid Libraries
Highly complexity NNK7 insertion capsid libraries (different serotypes and variable regions) for AAV capsid engineering and evolution
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AAV ACTOne GPCR Assay Kits
Live-cell-based cAMP biosensor systems for rapid and high-throughput functional screening of GPCRs
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AAV Services

Our commitment to quality, precision, and collaboration ensures that your projects are supported at every stage of development.  Explore our six core services, designed to accelerate your journey from concept to breakthrough.

AAV Vector
Design

AAV vector design and construction; AAV serotypes, promoter, and AAV production systems; AAV-shRNA/sgRNA design and screening

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AAV Packaging Services
Made in USA; High-quality; Fast turnaround; Affordable prices; Friendly custom services; ~ 20 year AAV experience
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AAV Characterization
Comprehensive AAV analytical services (capsid, genome, potency and safety) for both academia and industry
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AAV Library
Services
AAV library design, construction, production and evolution; AAV capsid library; AAV promoter/enhancer library; AAV-shRNA/sgRNA library
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AAV Capsid Development
Development of novel AAVs with ATHENA-I, ATHENA-II, ATHENA-III platform use both in vitro (cell lines, primary cells, organoids) and in vivo models
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AAV Experiment Services
Provide tailored services for all stages; AAV validation and biodistribution; AAV Nab Testing; AAV genome optimization; AAV Productivity test; AAV potency and rcAAV assays
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AAV Technologies

At AAVnerGene, we lead the way in transformative gene therapy solutions through state-of-the-art technological platforms.  Explore our three flagship technologies: AAVone single-plasmid AAV production system,  AAV-Q AAVTCID50 /rcAAV assays, and ATHENA capsid engineering platform.

AAV Production Systems, AAVone, AAVdual and AAVtri

AAVone Single-Plasmid AAV Production System

  • Use 1 plasmid instead of 3 plasmids for AAV production;
  • Achieves 2- to 4-fold higher productivity vs AAVtri; 
  • >50% full particle ratio across AAV serotypes;
  • Generate >5e15 VG/L titers for AAV9 in HEK 293 cells;
  • Reduce consumable  costs up to 78%;
  • Low plasmid-related impurities to less than 2.5%; 
  • Supported with high-efficiency transfection reagent (PEIone) and optimized HEK 293 cell line
AAVone
AAVdual
AAVtri
AAV-Q System for AAV potency and rcAAV assay

AAV-Q AAVTCID50/rcAAV Assay Platform

  • Three cell lines, two assays and one Rd-Ad vector;
  • Ultra-sensitive: Detects a single-copy.
  • Quick results: Turnaround within one week.
  • Broadly compatible: works with most AAV serotypes.
  • Safe design: Uses replication-defective Ad5.
  • Cost-efficient: streamlined qPCR workflow.
  • Highly consistent: Controlled assay conditions.
  • Reliable & robust: Low variability and high reproducibility
AAVTCID50 Assay
rcAAV Assay
ATHENA Capsid Engineering Platform

ATHENA AAV Capsid Engineering Platform

  • ATHENA-I selects AAVs for each target; 
  • ATHENA-II creates novel capsids using templates selected by ATHENA-I and -III;
  • ATHENA-III combines the benefits of AAV properties; 
  • ATHENA allows users to efficiently evaluate, evolve, and create AAV serotypes or variants tailored for specific therapeutic applications; 
  • Novel capsid AAV-ShD with super high DNA in NHP models: brain, lung…….
ATHENA-I
ATHENA-II
ATHENA-III

Why AAVnerGene

Tailored high-quality AAV solutions with expert collaboration.
AAV Expertise

We offer end-to-end solutions from vector design and packaging to capsid engineering and optimization. Our deep expertise ensures reliable, high-quality outcomes tailored to your gene therapy needs

Customizable & Innovative Solutions

We tailor GOI solutions, capsid library construction, and selection to meet unique client needs, delivering innovative solutions for complex projects

Rigorous Quality Standards

Our commitment to excellence ensures that every project undergoes stringent quality control, delivering consistent, reproducible results that comply with the highest industry standards

Collaborative Approach

We prioritize client partnerships. Our expert consultation services ensure seamless collaboration and a thorough understanding of your project goals for both success

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